Name Chan Sze Wa, Stella
Title Dr
Address Room 620B
Telephone 3653 6661
Email swchan@cihe.edu.hk
Office hours Monday – Friday 9 am – 6 pm
School Schools of Health Sciences

Biography

Dr. Stella Chan obtained her Bachelor's degree in Biology from the Hong Kong University of Science and Technology and her Postgraduate Diploma in Education from the Hong Kong Baptist University. She received her Ph.D. in Pharmacology from the Chinese University of Hong Kong in 2009 and completed post-doctoral training at the School of Biomedical Sciences and then at the Division of Clinical Pharmacology, Department of Medicine and Therapeutics, CUHK. Dr. Chan joined CIHE in 2012 as an Assistant Professor. She was appointed as Associate Professor in the School of Health Sciences in September 2016. Dr. Chan has been recognised as a Chartered Biologist by the Royal Society of Biology and serve as the Vice-chairman of the Royal Society of Biology Hong Kong Branch.

Teaching

Dr. Chan has taught a number of courses, including Human Anatomy and Physiology (BIOL112), Human Pathophysiology (BIOL113), Introduction to Pharmacology and Therapeutics (PHAR112), Pharmacology and Therapeutics II (PHAR215), Basic Pharmacology (HECA201), and Microbiology and Infection Control (HECA083). She has also taught nursing programmes in collaboration with the Hospital Authority and St. Teresa's hospital. Dr Chan has taught many subjects for the nursing schools, including Life Sciences, Introduction to Microbiology and Pharmacology, Human Biology and Clinical Microbiology.

Research

Our research focuses on the mechanism involved in feeding, nausea and emesis control. Nausea and emesis during drug treatment or disease can be debilitating and can severely impact on the quality of life. We use Suncus murinus as an animal model because common laboratory animals are incapable of emesis and therefore the potential of new chemical entities to induce nausea and emesis are usually missed in standard laboratory investigations. By using behavioural testing and surgical and radio-telemetric techniques coupled with immunohistochemistry, we collect information simultaneously on cardiovascular function and on the electrogastrogram during behavioural experimentation. We also collect information on the signalling pathways relative to feeding, nausea and emesis control mechanisms.

Research interest

Current competitive research grants

Co-Investigator. Novel Mechanisms Involved in Motion Sickness (HK$ 1,125,732) 2022-24.

Co-Investigator. Contribution of Disrupted Gastrointestinal Myoelectric Activity to Mechanisms of Cisplatin-Induced Acute and Delayed Nausea and Emesis (HK$ 996,285) 2021-23.

Principal Investigator. Anti-Emetic Potential of Cocaine- and Amphetamine-Regulated Transcript (CART) System in Suncus murinus (HK$ 959,200) 2020-2022.

Co-Investigator. Action of Ghrelin to Prevent Chemotherapy-Induced Side Effects in Suncus murinus (HK$ 864,742) 2019-21.

Principal Investigator. Potential Involvement of NUCB2/Nesfatin-1 in Emesis and Feeding in Suncus murinus (HK$ 1,271,537) 2017-2019.

Principal Investigator. Investigation of the Differential Roles of Centrally Located GLP-1 Receptors in Emesis and Feeding in Suncus murinus (HK$ 1,149,606). 2016-2018.

Selected Publications (*Corresponding author)

  1. Chan, S.W., Chu, T.T.W., Ho, C.S., Kong, A.P.S., Tomlinson, B., Zeng, W.W. (2021). Influence of CYP2D6 and CYP3A5 polymorphisms on the pharmacokinetics and pharmacodynamics of bisoprolol in hypertensive Chinese patients. Frontiers Medicine, 8, 1529. Doi:10.3389/fmed.2021.683498.
  2. Chan, S.W.#,*, Tomlinson, B.#,*, Chan, P., Lam, C.W.K. (2021). The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharmaceutical Biology. 59(1):1161-1171.
  3. Zeng, W.W.#, Chan, S.W.#, Tomlinson, B. (2021). Patient preferences for ambulatory blood pressure monitoring devices: Wrist-type or arm-type?. PloS one, 16(8), e0255871.

#These authors contributed equally to the manuscript

  1. Chan, S.W., Chu, T., Choi, S.W., Benzie, I., Tomlinson, B. (2021). Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytotherapy research: PTR, 35(6), 3236–3245.
  2. Lu, Z., Zhou, Y., Tu, L., Chan, S.W., Ngan, M. P., Cui, D., Liu, Y., Huang, I.B., Kung, J., Hui, C., Rudd, J.A. (2021). Sulprostone-induced gastric dysrhythmia in the ferret: conventional and advanced analytical approaches. Frontiers in physiology, 11, 583082.
  3. Liu, J., Du, P., Lu, Z., Kung, J., Huang, I. B., Hui, J., Ng, H., Ngan, M. P., Cui, D., Jiang, B., Chan, S. W.*, Rudd, J. A. (2021). Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum. Cell calcium, 97, 102417.
  4. Chan, S.W.*, Tomlinson, B.* (2020). Effects of Bilberry Supplementation on Metabolic and Cardiovascular Disease Risk. Molecules. 25, 1653; doi:10.3390/molecules25071653.
  5. Lu, Z., Chan, S.W.*, Tu, L., Ngan, M.P., & Rudd, J.A. (2020). GLP-1 receptors are involved in the GLP-1 (7–36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew). European Journal of Pharmacology, 888:173528.
  6. Rudd, J.A., Chan, S.W., Ngan, M.P., Tu, L., Lu, , Giuliano, C., Lovati, E., Pietra, C. (2018). Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew).Frontiers in Pharmacology Translational Pharmacology, 9. doi: 10.3389/fphar.2018.00869.
  7. Tu, L., Lu, Z., Dieser, K., Schmitt, C., Chan, S.W., Andrews, P.L.R., Nalivaiko, E., Rudd, J.A. (2017). Brain Activation by H1 Antihistamines Challenges Conventional View of their Mechanism of Action in Motion Sickness: A Behavioural, c-Fos and Physiological Study in Suncus murinus(House Musk Shrew). Frontiers in Physiology,8. doi: 10.3389/fphys.2017.00412
  8. Ullaha, I., Subhanb, F., Lu, Z., Chan, S., Rudd, J.A. (2017). Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus(house musk shrew). Journal of Pharmacological Sciences,133(4), 232-239.
  9. Chan, S.W., Xiao, Y., Hu, M., Yin, Q.P., Chu, T.T.W., Fok, B.S.P., Lee, V.H.L., Tomlinson, B. (2016). Associations of the CYP3A5*3and CYP3A4*1Gpolymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese. Journal of Clinical Pharmacy and Therapeutics,41(5), 552-558.
  10. Lu,, Percie Du Sert, N. Chan, S.W., Yeung, C.K., Lin, G., Yew, D.T.W., Andrews, P.L.R., Rudd, J.A. (2014). Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret, Journal of Translational Medicine, 12(1), 327.
  11. Chan, S.W., Lu, Z., Yew, D.T.W., Yeung, C.K., Rudd, J.A. (2014). The differential antiemetic properties of GLP-1 antagonist, exendin (9-39) in Suncus murinus(house musk shrew).Neuropharmacology, 83, 71-78.
  12. Chan, S.W., Lin, G., Yew, D.T.W., Yeung, C.K., Rudd, J.A. (2013). Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus(house musk shrew). Neuropharmacology, 70, 141-147.
  13. Chan, S.W., Hu, M., Ko, S.S.W., Tam, C.W.Y., Fok, B.S.P., Yin, O.Q.P., Chow, M.S.S., Tomlinson, B. (2013). CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects. European Journal of Clinical Pharmacology. 36, 799-806.
  14. Chan, S.W., Hu, M., Walden, R., Tomlinson, B. (2012). The pharmacogenetics of β-adrenergic receptor antagonists in the treatment of hypertension and heart failure. Expert Opinion on Drug Metabolism & Toxicology, 8(7),767-790.
  15. Chan, S.W., Lin, G., Yew, D.T.W., Rudd, J. A. (2011). A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew). European Journal of Pharmacology, 668, 340-346.
  16. Chan, S.W., Lin, G., Yamamoto, K., Yew, D.T.W., Rudd, J. A. (2010). Simultaneous determination of amino acids in discrete brain areas in Suncus murinusby high performance liquid chromatography with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis,53(3), 705-709.
  17. Yamamoto, K., Chan, S.W., Rudd, J.A., Lin, G., Asano, K., Yamatodani, A. (2009). Involvement of hypothalamic glutamate in cisplatin-induced emesis in Suncus murinus (house musk shrew). Journal of Pharmacological Sciences, 109(4), 631-634.


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