姓名 陈诗华
称谓 副教授
地址 620B
电话号码 (852) 3653 6661
电邮 swchan@sfu.edu.hk
办公时间 星期一至五上午九时至下午六时
学院 余兆麒健康科学院

背景简介

陈博士在香港科技大学获得生物学学士学位，之后在香港浸会大学获得教育学深造文凭，并在香港中文大学获得药理学博士学位。她先后在母校香港中文大学生物医学学院和内科及药物治疗学系临床药理学部完成博士后研究。陈博士拥有超过 15 年的研究经验，专注于与餵食噁心呕吐控制、糖尿病和心血管疾病相关的机制，是英国皇家生物学会的特许生物学家，并于 2024 年 4 月被理事会选为英国皇家生物学会院士以表彰她对生物科学的贡献以及整个职业生涯中具有影响力的经历。她于2012年加入SFU担任助理教授，并于2016年成为健康科学学院副教授，同时担任香港生物学会主席、Gut Rhythm R&D (HK) Ltd顾问专业药理学家以及香港中文大学生物医学学院肿瘤生物学及实验药物治疗学主题研究组成员。

教学

陈博士曾任教的科目包括人体解剖学与生理学 (BIOL112) 、生物与生命科学 (HDE102) 、人体病理生理学 (BIOL113) 、药理学及治疗学导论(PHAR112) 、药理学及治疗学 (二) (PHAR215) 、基本药理学 (HECA201) 、微生物学及感染控制 (HECA083) 以及微生物学与护理 (NUR103)。她同时任教医院管理局护理学课程、圣德肋撒医院护理学课程以及仁安医院护理学课程。陈博士曾任教的科目包括生命科学、微生物学与药理学导论、人类生物学及临床微生物学。

研究

噁心和呕吐，无论是在药物治疗后还是由于疾病诱发，都可能令人虚弱。我们使用鼩鼱作为动物模型，因为常用的实验室动物不能呕吐，因此新化学成份诱发噁心和呕吐的潜力在标准实验研究中经常被忽略。我们通过使用行为测试、手术和无线电遥测技术，再加上免疫组织化学，可以同时收集一系列相关数据，包括行为实验期间的心血管功能和胃动力，还可以获得与进食、噁心和呕吐控制机制相关的信号通路，以补充和证实其他数据。

研究兴趣

研究资助


RGC – Faculty Development Scheme首席调查员。阐明下丘脑 GLP-1 受体系统在鼩鼱噁心和呕吐机制中的新作用 (HK$ 1,1361,479) ，2023-2025。

RGC – General Research Fund联合调查员。晕动病的新机制研究 (HK$ 1,125,732)，2022-24。

RGC – General Research Fund联合调查员。胃肠道肌电活动失调在顺铂引起的急性和延迟性噁心和呕吐机制中的作用 (HK$ 996,285) ， 2021-23。

RGC – Faculty Development Scheme首席调查员。可卡因－苯丙胺调节转录（CART）系统在鼩鼱的潜在止吐作用 (HK$ 959,200) ，2020-2022。

RGC – General Research Fund联合调查员。胃饥饿素抑制化学疗法在鼩鼱上引起的副作用  (HK$ 864,742) ， 2019-21。

RGC – Faculty Development Scheme首席调查员。NUCB2/nesfatin-1在鼩鼱呕吐及摄食的潜在作用 (HK$ 1,271,537) ， 2017-2019。

RGC – Faculty Development Scheme首席调查员。研究中枢GLP-1受体对鼩鼱呕吐及摄食的不同作用  (HK$ 1,149,606) ， 2016-2018。

着作选录


学术书藉 

      1. Tomlinson, B., Chan, S. W., & Chan, P. (2023). Lingzhi (Ganoderma lucidum) and Cardiovascular Disease. In Rajkumar Rajendram, Vinood Patel, Victor Preedy (Ed.). Ancient and Traditional Foods, Plants, Herbs and Spices used in Cardiovascular Health and Disease. Boca Raton: CRC Press.

 

        1. Chan, S. W.* & Tomlinson, B. (2023). Beneficial effects of Bilberry (Vaccinium myrtillus) in diabetes and cardiovascular disease. In Rajkumar Rajendram, Vinood Patel, Victor Preedy (Ed.). Ancient and Traditional Foods, Plants, Herbs and Spices used in Diabetes. Boca Raton: CRC Press.

学术论文

  1. Yang, L., Kung, C. J. S., Lu, Z., Liu, J. Y. H., Ngan, M. P., Sakai, T., Sakata, I., Chan, S. W., Tu, L., & Rudd, J. A. (2024). Exploring the role of ghrelin and des-acyl ghrelin in chemotherapy-induced nausea and vomiting. Neuropharmacology, 251, 109919.

 

  1. Liu, J. Y. H., Deng, Y., Hui, J. C. M., Du, P., Ng, H. S. H., Lu, Z., Yang, L., Liu, L., Khalid, A., Ngan, M. P., Cui, D., Jiang, B., Chan, S. W., & Rudd, J. A. (2023). Regional differences of tachykinin effects on smooth muscle and pacemaker potentials of the stomach, duodenum, ileum and colon of an emetic model, the house musk shrews. Neuropeptides, 97, 102300.

 

  1. Zeng, W., Chu, T. T. W., Ho, C. S., Lo, C. W. S., Chan, A. S. L., Kong, A. P. S., Tomlinson, B., & Chan, S. W.* (2022). Lack of effects of renin-angiotensin-aldosterone system activity and beta-adrenoceptor pathway polymorphisms on the response to bisoprolol in hypertension. Front Cardiovasc Med, 9, 842875.

 

  1. Lu, Z., Cui, D., Liu, J. Y. H., Jiang, B., Ngan, M. P., Sakata, I., Takemi, S., Sakai, T., Lin, G., Chan, S. W.*, & Rudd, J. A. (2022). The actions of centrally administered nesfatin-1 on emesis, feeding, and locomotor activity in Suncus murinus (House Musk Shrew). Front Pharmacol, 13, 858522.

 

  1. Chan, S. W., Chu, T. T. W., Ho, C. S., Kong, A. P. S., Tomlinson, B., & Zeng, W. (2021). Influence of CYP2D6 and CYP3A5 polymorphisms on the pharmacokinetics and pharmacodynamics of bisoprolol in hypertensive Chinese patients. Front Med (Lausanne), 8, 683498.

 

  1. Chan, S. W.*, Tomlinson, B., Chan, P., & Lam, C. W. K. (2021). The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharm Biol, 59(1), 1161-1171.

 

  1. Zeng, W. W., Chan, S. W., & Tomlinson, B. (2021). Patient preferences for ambulatory blood pressure monitoring devices: Wrist-type or arm-type? PLoS One, 16(8), e0255871.

 

  1. Chan, S. W., Chu, T. T. W., Choi, S. W., Benzie, I. F. F., & Tomlinson, B. (2021). Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res, 35(6), 3236-3245.

 

  1. Liu, J. Y. H., Du, P., Lu, Z., Kung, J. S. C., Huang, I. B., Hui, J. C. M., Ng, H. S. H., Ngan, M. P., Cui, D., Jiang, B., Chan, S. W., & Rudd, J. A. (2021). Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum. Cell Calcium, 97, 102417.

 

  1. Lu, Z., Chan, S. W.*, Tu, L., Ngan, M. P., & Rudd, J. A. (2020). GLP-1 receptors are involved in the GLP-1 (7-36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew). Eur J Pharmacol, 888, 173528.
  2. Lu, Z., Zhou, Y., Tu, L., Chan, S. W., Ngan, M. P., Cui, D., Liu, Y. H. J., Huang, I. B., Kung, J. S. C., Hui, C. M. J., & Rudd, J. A. (2020). Sulprostone-induced gastric dysrhythmia in the ferret: Conventional and advanced analytical approaches. Front Physiol, 11, 583082.

 

 

  1. Chan, S. W.*, & Tomlinson, B. (2020). Effects of bilberry supplementation on metabolic and cardiovascular disease risk. Molecules, 25(7).

 

  1. Rudd, J. A., Chan, S. W., Ngan, M. P., Tu, L., Lu, Z., Giuliano, C., Lovati, E., & Pietra, C. (2018). Corrigendum: Anti-emetic action of the brain-penetrating new ghrelin agonist, HM01, alone and in combination with the 5-HT3 antagonist, palonosetron and with the NK1 antagonist, netupitant, against cisplatin- and motion-induced emesis in Suncus murinus (House Musk Shrew). Front Pharmacol, 9, 1102.

 

  1. Ullah, I., Subhan, F., Lu, Z., Chan, S. W., & Rudd, J. A. (2017). Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew). J Pharmacol Sci, 133(4), 232-239.

 

  1. Tu, L., Lu, Z., Dieser, K., Schmitt, C., Chan, S. W., Ngan, M. P., Andrews, P. L. R., Nalivaiko, E., & Rudd, J. A. (2017). Brain activation by H1 antihistamines challenges conventional view of their mechanism of action in motion sickness: A behavioral, c-Fos and physiological study in Suncus murinus (House Musk Shrew). Front Physiol, 8, 412.

 

  1. Chan, S. W., Xiao, Y., Hu, M., Yin, O. Q., Chu, T. T., Fok, B. S., Lee, V. H., & Tomlinson, B. (2016). Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6beta-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese. J Clin Pharm Ther, 41(5), 552-558.

 

  1. Chan, S. W., Lu, Z., Lin, G., Yew, D. T., Yeung, C. K., & Rudd, J. A. (2014). The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew). Neuropharmacology, 83, 71-78.

 

  1. Lu, Z., Percie Du Sert, N., Chan, S. W., Yeung, C. K., Lin, G., Yew, D. T., Andrews, P. L., & Rudd, J. A. (2014). Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret. J Transl Med, 12, 327.

 

  1. Chan, S. W., Hu, M., Ko, S. S., Tam, C. W., Fok, B. S., Yin, O. Q., Chow, M. S., & Tomlinson, B. (2013). CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects. Eur J Clin Pharmacol, 69(4), 799-806.

 

  1. Chan, S. W., Lin, G., Yew, D. T., Yeung, C. K., & Rudd, J. A. (2013). Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew). Neuropharmacology, 70, 141-147.

 

  1. Hu, M., Yang, Y. L., Fok, B. S., Chan, S. W., Chu, T. T., Poon, E. W., Yin, O. Q., Lee, V. H., & Tomlinson, B. (2012). Effects of CYP2D6*10, CYP3A5*3, CYP1A2*1F, and ABCB1 C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects. Drug Metabol Drug Interact, 27(1), 33-39.

 

  1. Chan, S. W., Hu, M., & Tomlinson, B. (2012). The pharmacogenetics of beta-adrenergic receptor antagonists in the treatment of hypertension and heart failure. Expert Opin Drug Metab Toxicol, 8(7), 767-790.

 

  1. Xiao, Y. J., Chan, S. W., Hu, M., Chu, T. T. W., Fok, B. S. P., Poon, E. W. M., & Tomlinson, B. (2012). Simultaneous determination of cortisol, cortisone, and 6 beta-hydroxycortisol in human urine by UPLC with UV detector and application to determine diurnal variations. Chromatographia, 75(3-4), 169-173.

 

  1. Chan, S. W., Lin, G., Yew, D. T., & Rudd, J. A. (2011). A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew). Eur J Pharmacol, 668(1-2), 340-346.

 

  1. Yang, Y., Chan, S. W., Hu, M., R., W., & Tomlinson, B. (2011). Effects of some common food constituents on cardiovascular disease. ISRN Cardiology, 397136.

 

  1. Chan, S. W., Lin, G., Yamamoto, K., Yew, D. T., & Rudd, J. A. (2010). Simultaneous determination of amino acids in discrete brain areas in Suncus murinus by high performance liquid chromatography with electrochemical detection. J Pharm Biomed Anal, 53(3), 705-709.

 

  1. Yamamoto, K., Chan, S. W., Rudd, J. A., Lin, G., Asano, K., & Yamatodani, A. (2009). Involvement of hypothalamic glutamate in cisplatin-induced emesis in Suncus murinus (house musk shrew). J Pharmacol Sci, 109(4), 631-634.

 

  1. Cheng, F. H., Chan, S. W., & Rudd, J. A. (2008). Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum. Neuropeptides, 42(5-6), 671-679.

 

  1. Chan, S. W., He, J., Lin, G., Rudd, J. A., & Yamamoto, K. (2007). Action of GLP-1 (7-36) amide and exendin-4 on Suncus murinus (house musk shrew) isolated ileum. Eur J Pharmacol, 566(1-3), 185-191.

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