姓名 陳詩華
稱謂 副教授
地址 香港新界將軍澳翠嶺里2號明愛專上學院620B室
電話號碼 (852) 3653 6661
電郵 swchan@cihe.edu.hk
辦公時間 星期一至五上午九時至下午六時
學院 健康科學院

背景簡介

獲得香港科技大學生物學學士學位及香港浸會大學
教育學深造文憑後，陳博士於生物醫學學院取得藥理學博士學位，先後在母校生物醫學學院和內科及藥物治療學系臨床藥理學部完成博士後研究。 15 年來，陳博士一直參與臨床前和臨床研究，重點關注與進食、噁心、嘔吐控制、糖尿病和心血管疾病相關的機制。陳博士於2012年加入明愛專上學院擔任助理教授，並於2016年獲委任為健康科學學院副教授。陳博士亦為英國皇家生物學會特許生物學家，香港生物學會主席，Gut Rhythm R&D (HK) Ltd顧問專業藥理學家，以及香港中文大學生物醫學學院腫瘤生物學及實驗藥物治療學主題研究組成員。

教學

陳博士曾任教的科目包括人體解剖學與生理學 (BIOL112) 、生物與生命科學 (HDE102) 、人體病理生理學 (BIOL113) 、藥理學及治療學導論(PHAR112) 、藥理學及治療學 (二) (PHAR215) 、基本藥理學 (HECA201) 、微生物學及感染控制 (HECA083) 以及微生物學與護理 (NUR103)。她同時任教醫院管理局護理學課程、聖德肋撒醫院護理學課程以及仁安醫院護理學課程。陳博士曾任教的科目包括生命科學、微生物學與藥理學導論、人類生物學及臨床微生物學。

研究

噁心和嘔吐，無論是在藥物治療後還是由於疾病誘發，都可能令人虛弱。我們使用鼩鼱作為動物模型，因為常用的實驗室動物不能嘔吐，因此新化學成份誘發噁心和嘔吐的潛力在標準實驗研究中經常被忽略。我們通過使用行為測試、手術和無線電遙測技術，再加上免疫組織化學，可以同時收集一系列相關數據，包括行為實驗期間的心血管功能和胃動力，還可以獲得與進食、噁心和嘔吐控制機制相關的信號通路，以補充和證實其他數據。

研究興趣

研究資助


RGC – Faculty Development Scheme首席調查員。闡明下丘腦 GLP-1 受體系統在鼩鼱噁心和嘔吐機制中的新作用 (HK$ 1,1361,479) ，2023-2025。

RGC – General Research Fund聯合調查員。暈動病的新機制研究 (HK$ 1,125,732)，2022-24。

RGC – General Research Fund聯合調查員。胃腸道肌電活動失調在順鉑引起的急性和延遲性噁心和嘔吐機制中的作用 (HK$ 996,285) ， 2021-23。

RGC – Faculty Development Scheme首席調查員。可卡因－苯丙胺調節轉錄（CART）系統在鼩鼱的潛在止吐作用 (HK$ 959,200) ，2020-2022。

RGC – General Research Fund聯合調查員。胃飢餓素抑制化學療法在鼩鼱上引起的副作用  (HK$ 864,742) ， 2019-21。

RGC – Faculty Development Scheme首席調查員。NUCB2/nesfatin-1在鼩鼱嘔吐及攝食的潛在作用 (HK$ 1,271,537) ， 2017-2019。

RGC – Faculty Development Scheme首席調查員。研究中樞GLP-1受體對鼩鼱嘔吐及攝食的不同作用  (HK$ 1,149,606) ， 2016-2018。

著作選錄


學術書藉 

      1. Tomlinson, B., Chan, S. W., & Chan, P. (2023). Lingzhi (Ganoderma lucidum) and Cardiovascular Disease. In Rajkumar Rajendram, Vinood Patel, Victor Preedy (Ed.). Ancient and Traditional Foods, Plants, Herbs and Spices used in Cardiovascular Health and Disease. Boca Raton: CRC Press.

 

        1. Chan, S. W.* & Tomlinson, B. (2023). Beneficial effects of Bilberry (Vaccinium myrtillus) in diabetes and cardiovascular disease. In Rajkumar Rajendram, Vinood Patel, Victor Preedy (Ed.). Ancient and Traditional Foods, Plants, Herbs and Spices used in Diabetes. Boca Raton: CRC Press.

學術論文

        1. Liu, J. Y. H., Deng, Y., Hui, J. C. M., Du, P., Ng, H. S. H., Lu, Z., Yang, L., Liu, L., Khalid, A., Ngan, M. P., Cui, D., Jiang, B., Chan, S. W., & Rudd, J. A. (2023). Regional differences of tachykinin effects on smooth muscle and pacemaker potentials of the stomach, duodenum, ileum and colon of an emetic model, the house musk shrews. Neuropeptides, 97, 102300.

 

        1. Zeng, W., Chu, T. T. W., Ho, C. S., Lo, C. W. S., Chan, A. S. L., Kong, A. P. S., Tomlinson, B., & Chan, S. W.* (2022). Lack of effects of renin-angiotensin-aldosterone system activity and beta-adrenoceptor pathway polymorphisms on the response to bisoprolol in hypertension. Front Cardiovasc Med, 9, 842875.

 

        1. Lu, Z., Cui, D., Liu, J. Y. H., Jiang, B., Ngan, M. P., Sakata, I., Takemi, S., Sakai, T., Lin, G., Chan, S. W.*, & Rudd, J. A. (2022). The actions of centrally administered nesfatin-1 on emesis, feeding, and locomotor activity in Suncus murinus (House Musk Shrew). Front Pharmacol, 13, 858522.

 

        1. Chan, S. W., Chu, T. T. W., Ho, C. S., Kong, A. P. S., Tomlinson, B., & Zeng, W. (2021). Influence of CYP2D6 and CYP3A5 polymorphisms on the pharmacokinetics and pharmacodynamics of bisoprolol in hypertensive Chinese patients. Front Med (Lausanne), 8, 683498.

 

        1. Chan, S. W.*, Tomlinson, B., Chan, P., & Lam, C. W. K. (2021). The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharm Biol, 59(1), 1161-1171.

 

        1. Zeng, W. W., Chan, S. W., & Tomlinson, B. (2021). Patient preferences for ambulatory blood pressure monitoring devices: Wrist-type or arm-type? PLoS One, 16(8), e0255871.

 

        1. Chan, S. W., Chu, T. T. W., Choi, S. W., Benzie, I. F. F., & Tomlinson, B. (2021). Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res, 35(6), 3236-3245.

 

        1. Liu, J. Y. H., Du, P., Lu, Z., Kung, J. S. C., Huang, I. B., Hui, J. C. M., Ng, H. S. H., Ngan, M. P., Cui, D., Jiang, B., Chan, S. W., & Rudd, J. A. (2021). Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum. Cell Calcium, 97, 102417.

 

          1. Lu, Z., Chan, S. W.*, Tu, L., Ngan, M. P., & Rudd, J. A. (2020). GLP-1 receptors are involved in the GLP-1 (7-36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew). Eur J Pharmacol, 888, 173528.

 

            1. Lu, Z., Zhou, Y., Tu, L., Chan, S. W., Ngan, M. P., Cui, D., Liu, Y. H. J., Huang, I. B., Kung, J. S. C., Hui, C. M. J., & Rudd, J. A. (2020). Sulprostone-induced gastric dysrhythmia in the ferret: Conventional and advanced analytical approaches. Front Physiol, 11, 583082.

 

            1. Chan, S. W.*, & Tomlinson, B. (2020). Effects of bilberry supplementation on metabolic and cardiovascular disease risk. Molecules, 25(7).

 

            1. Rudd, J. A., Chan, S. W., Ngan, M. P., Tu, L., Lu, Z., Giuliano, C., Lovati, E., & Pietra, C. (2018). Corrigendum: Anti-emetic action of the brain-penetrating new ghrelin agonist, HM01, alone and in combination with the 5-HT3 antagonist, palonosetron and with the NK1 antagonist, netupitant, against cisplatin- and motion-induced emesis in Suncus murinus (House Musk Shrew). Front Pharmacol, 9, 1102.

 

            1. Ullah, I., Subhan, F., Lu, Z., Chan, S. W., & Rudd, J. A. (2017). Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew). J Pharmacol Sci, 133(4), 232-239.

 

            1. Tu, L., Lu, Z., Dieser, K., Schmitt, C., Chan, S. W., Ngan, M. P., Andrews, P. L. R., Nalivaiko, E., & Rudd, J. A. (2017). Brain activation by H1 antihistamines challenges conventional view of their mechanism of action in motion sickness: A behavioral, c-Fos and physiological study in Suncus murinus (House Musk Shrew). Front Physiol, 8, 412.

 

            1. Chan, S. W., Xiao, Y., Hu, M., Yin, O. Q., Chu, T. T., Fok, B. S., Lee, V. H., & Tomlinson, B. (2016). Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6beta-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese. J Clin Pharm Ther, 41(5), 552-558.

 

            1. Chan, S. W., Lu, Z., Lin, G., Yew, D. T., Yeung, C. K., & Rudd, J. A. (2014). The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew). Neuropharmacology, 83, 71-78.

 

            1. Lu, Z., Percie Du Sert, N., Chan, S. W., Yeung, C. K., Lin, G., Yew, D. T., Andrews, P. L., & Rudd, J. A. (2014). Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret. J Transl Med, 12, 327.

 

            1. Chan, S. W., Hu, M., Ko, S. S., Tam, C. W., Fok, B. S., Yin, O. Q., Chow, M. S., & Tomlinson, B. (2013). CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects. Eur J Clin Pharmacol, 69(4), 799-806.

 

            1. Chan, S. W., Lin, G., Yew, D. T., Yeung, C. K., & Rudd, J. A. (2013). Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew). Neuropharmacology, 70, 141-147.

 

            1. Hu, M., Yang, Y. L., Fok, B. S., Chan, S. W., Chu, T. T., Poon, E. W., Yin, O. Q., Lee, V. H., & Tomlinson, B. (2012). Effects of CYP2D6*10, CYP3A5*3, CYP1A2*1F, and ABCB1 C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects. Drug Metabol Drug Interact, 27(1), 33-39.

 

            1. Chan, S. W., Hu, M., & Tomlinson, B. (2012). The pharmacogenetics of beta-adrenergic receptor antagonists in the treatment of hypertension and heart failure. Expert Opin Drug Metab Toxicol, 8(7), 767-790.

 

            1. Xiao, Y. J., Chan, S. W., Hu, M., Chu, T. T. W., Fok, B. S. P., Poon, E. W. M., & Tomlinson, B. (2012). Simultaneous determination of cortisol, cortisone, and 6 beta-hydroxycortisol in human urine by UPLC with UV detector and application to determine diurnal variations. Chromatographia, 75(3-4), 169-173.

 

            1. Chan, S. W., Lin, G., Yew, D. T., & Rudd, J. A. (2011). A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew). Eur J Pharmacol, 668(1-2), 340-346.

 

            1. Yang, Y., Chan, S. W., Hu, M., R., W., & Tomlinson, B. (2011). Effects of some common food constituents on cardiovascular disease. ISRN Cardiology, 397136.

 

            1. Chan, S. W., Lin, G., Yamamoto, K., Yew, D. T., & Rudd, J. A. (2010). Simultaneous determination of amino acids in discrete brain areas in Suncus murinus by high performance liquid chromatography with electrochemical detection. J Pharm Biomed Anal, 53(3), 705-709.

 

            1. Yamamoto, K., Chan, S. W., Rudd, J. A., Lin, G., Asano, K., & Yamatodani, A. (2009). Involvement of hypothalamic glutamate in cisplatin-induced emesis in Suncus murinus (house musk shrew). J Pharmacol Sci, 109(4), 631-634.

 

              1. Cheng, F. H., Chan, S. W., & Rudd, J. A. (2008). Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum. Neuropeptides, 42(5-6), 671-679.

 

                1. Chan, S. W., He, J., Lin, G., Rudd, J. A., & Yamamoto, K. (2007). Action of GLP-1 (7-36) amide and exendin-4 on Suncus murinus (house musk shrew) isolated ileum. Eur J Pharmacol, 566(1-3), 185-191.

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